Cognitive trajectories in amyloid positive and negative subjects

 
   Lead Investigator:    Richard Caselli
   Institution      :    Arizona Mayo ADC
   E-Mail           :    caselli.richard@mayo.edu
   Proposal ID      :    869



   Proposal Description:
   We will examine the neuropsychological profile of patients diagnosed with AD      and controlling for disease severity to see if there is a difference in the       cognitive profiles of those who were amyloid positive vs amyloid negative.        The study implications could be:                                                  1.  there is no difference in which case this would be c/w previous studies,      including our own showing that there is no differential acceleration of           frontally mediated cognition preclinically in e4 carriers despite the early       accumulation of amyloid in the frontal lobes.                                     2.  there is a difference and amyloid positive patients have greater frontal      decline (on relevant tests) due to the excess burden of frontal amyloid           pathology.                                                                        3.  there is a difference and the amyloid negative patients actually have         greater frontal impairment due to a lack of amyloid fending off NFT